Including over 1,000 Orthodontists and 400 students

Dubai, United Arab Emirates – July 8, 2020: Align Technology, Inc. (NASDAQ: ALGN), today reported on the highlights of its first digital Invisalign Scientific Symposium, held on May 15-16, 2020.


The 2020 Invisalign Scientific Symposium was conducted from a TV studio and featured a roster of global clinical and orthodontic speakers who, shared scientific data and their best practices for treating Class II, deep bite and surgical cases, in both adult and growing patient populations, including Phase 1 treatments for younger patients and the Invisalign system with mandibular advancement for teenagers.

The virtual format reflected Align Technology’s ongoing commitment to sharing forward-thinking knowledge and arming specialist orthodontists and dental practitioners with clinical sessions to help them learn from their peers, exchange best practices and move forward with their own clinics.


The Scientific Symposium attracted 1,400 delegates, including over 1,000 orthodontists and 400 university students from 75 countries worldwide. The event was moderated by Dr. Beena Harkison (until recently Align’s Clinical & Professional Education Director, EMEA), who highlighted clinical data on the use of the Invisalign system compared with traditional treatments and Invisalign system’s capabilities versus fixed appliances.


Dr. Alessandro Greco who runs an orthodontic practice in Rome that focuses exclusively on the Invisalign system, was the first clinical presenter. In his lecture “Changing the Paradigm of Deep Bite Treatment with Invisalign Aligners”, he addressed the perception of aligners and their capacity to help patients with deep bites. He used the case of a 14-year-old teenager to demonstrate the use of the Invisalign system’s G5 features, including bite ramps and pressure areas. Dr. Greco commented that the G5 protocol using Invisalign aligners proved to be not only an effective approach for the correction of severe deep bite, but also efficiently reduced the overall treatment time, requiring fewer additional aligners.

Dr. Dieter Brothag, a digital orthodontist from Germany presented ‘Retrospective Review of Invisalign Aligners and Fixed Appliances’, a topic he chose after being repeatedly asked whether the Invisalign system delivers the same clinical results as fixed appliances for younger patients. Dr. Brothag compared clinical outcomes using the two techniques, focusing on a sample of 25 fixed appliance treatments and 25 Invisalign aligner patients. Dr. Brothag concluded his presentation by saying that the Invisalign system was a tremendous practice builder which is proven to be much faster than fixed appliances while offering more comfort, greater hygiene and clinical success.

While presenting “Skeletal and Dentoalveolar Effects Produced by Aligners and Elastics in Class II Growing Patients,’ Dr. Federico Migliori from Italy spoke about the predictability of distalising with aligners, referencing the systematic review by Rossini in 2017 which states that 2.5mm is predictable. The study looked at 14 patients aged around 14 years of age, which were compared to a control group treated with fixed appliances. The conclusion of the study showed that using the Invisalign system with class II elastics and distalisation was predictable and Invisalign aligners were more effective at controlling the vertical dimension and lower incisor proclination. Distalisation was achieved in an average of 15 months, which was shorter than treatments completed with fixed appliances.

Dr. Simona Dianiskova from Slovakia shared her presentation “Correction of Class II Malocclusion in Growing Patients with Aligners” and discussed how they de-rotated upper 1st molars – up to 2mm (as85% of class II cases have rotated upper 1st molars), with expansion to correct a Class II malocclusion. Dr. Dianiskova showed that there was a significant statistical increase in condylar distance. The conclusion was a greater response of the mandible with expected growth using class II elastics and the Invisalign system, with good vertical control. The duration of treatment was between 16 and 21 months.

Another clinical study focused on ‘Class II Malocclusion Treated with Invisalign with Mandibular Advancement Feature and compared with historical controls of Twin Block Appliances. Dr. Sandra Tai’s study looked at the Invisalign system with mandibular advancement compared with twin blocks in 32 patients with an average age of 13.  The study concluded that there was better skeletal change using mandibular advancement with the Invisalign system, as well as better control of low incisor inclination. The study also found that mandibular growth was enhanced, and Invisalign aligners controlled the vertical dimension very well.

This study, along with Dr. Dianiskova’s using class II elastics and the Invisalign system for distalising or mandibular advancement, both showed that there were no/minimal changes to the incisor inclination.

There were two studies on the topic of expansion presented at the Symposium. The first was by Dr. Silvia Caruso from Italy who presented “Arch Expansion Pattern Using Clear Aligners: A Three-dimensional Retrospective Study in Paediatric Subjects with Posterior Crossbite.” The orthodontists conducting the study wanted to assess the amount of expansion which can be achieved using the Invisalign First system. They looked at the cases of 20 patients between the ages of 6 and 10 with moderate to severe crowding and analyzed the data retrospectively, reviewing the maxillary dentition, gingival width and buccal cusp width of the teeth.  They found that the most predictable expansion took place in the buccal cusps between the primary canines. The least predictable on the buccal cusps was at the first permanent molar to the first permanent molar. The study concluded that using the Invisalign First system for expansion is predictable on the buccal cusps Palatable expansion was predictable in the C-C region and less predictable in the molar regions. Dr. Caruso summarized by providing her top tips for improving the predictability on the palatal cusps.

The duo of Dr. Tommaso Castroflorio and Dr. Francesco Garino also presented a study relating to Invisalign First: “Invisalign First: Maxillary Expansion with Aligners in Growing Patients.”  The study presented by Drs. Castroflorio and Garino was similar to a study by Dr. Silvia Caruso. The study cohort comprised 43 patients aged 8 years of age. The authors found that expansion was the greatest between primary canine to the primary canine region, achieving more than 3mm of expansion.

These two studies showed that expansion can be achieved using aligners. It also demonstrates that this is greater in the anterior region, than in the posterior, and it is more predictable in the buccal plane than it is in the palatal plane. Both studies showed that using Invisalign First resulted in an increase in the volume of the palate.

During his lecture about “Impacted Teeth in Growing Patients,”’ Dr. David Couchat from France commented: “The tracking of an impacted tooth is always a challenge but since I have been using the Invisalign system, it became finally easier and better. The situation is completely different if you consider tracking a tooth for an adult or a teen. He also presented his tips and techniques to be successful with impacted teeth.”

Align Technology also used the Symposium as a platform to preview other campaigns that it plans to launch this year to further support digital orthodontics, starting with an upcoming marketing campaign entitled “Invis Is Your Brilliance. Enhanced”.
                                                                                                                                                        Peer recognition

Align Technology also offered attendees the opportunity to achieve recognition for their own successful Invisalign treatment cases. The case with the most votes was one from Dr. Mercedes Revenaz, Specialist Orthodontist from Bologna, Italy and a recent Invisalign speaker. Second place was for Dr. Martin Pedernera from Spain who had been voted Winner of the 2018 Invisalign Peer Review Award and third was Dr. Cihan Capan from Turkey, Orthodontist, Founder & Board Member of DentGroup Clinics, Invisalign provider and President of the Turkish Aligner Society.
Commenting on her win, Dr. Mercedes Revenaz stated: “The digital edition of the Align Scientific Symposium, in my opinion, was a revelation in terms of the impact. The event was informative and was likely watched more carefully than any other live event. This is easy to explain as it has been followed by doctors who use the Invisalign system, are digital natives, and believe in the power of digital technology. It could only be a success! We all hope that in the near future, if the conditions are right, international events can be at least a hybrid, with the possibility of being followed live, but also via web.”

Continued Dr Revenaz: “I was so thrilled when Dr. Mitra Derakhshan announced the award for my case. It makes me believe that what I do for my patients every day is really important! I would really like to share my experience of Invisalign treatment with really young patients, because I love to use digital workflow for children, they really appreciate it.”


World Health Organisation Donation


Align Technology made a pledge to donate €50 to the World Health Organisation in the fight against COVID-19 for each Symposium registered participant, with a total donation of €70,000.


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